pentobarbital will lower the level or impact of lefamulin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Stay away from coadministration of lefamulin with potent or reasonable CYP3A inducers unless the benefit outweighs pitfalls. Monitor for diminished efficacy.pentobarbital boosts toxicity of ifosfamide by